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KMID : 0380319910480000089
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Journal of Korean Research Institute for Better Living
1991 Volume.48 No. 0 p.89 ~ p.93
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Effect of Magnesium Sulfate on the Systemic Toxicity of Bupivacaine in the Rabbits
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Abstract
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Intravenous injection of local anesthetics during epidural anesthesia is often associated with convulsion, respiratory arrest and death. Continous epidural anesthesia is being used with increasing frequency in the obstetric population. However, parturients may be at increased risk for developing local anethetic toxicity, becasus of physiologic change of pregnancy. The increased sensitivity of pregnant animal is specific to bupivacaine. Magnesium sulfate(MgSO_4) is useful in preventing & treating eclamptic seizures. Parturients receiving magnesium sulfate frequently become candidate for epidural anesthesia.
Spielman et al. noted that magnesium potentiates the cardiac toxicity of bupivacaine. The purpose of this study was to investigated the effect of magnesium on the systemic toxicity of bupivacaine in rabbits.
Mean dosages of bupivacaine administered up to the onset of convulsion, apnea and circulatory collapse are higher in the MgSO_4 pretreated group as compared to the control group. In conclusion, small dosages of MgSO_4 does not potentiate the systemic toxicity of bupivacaine.
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